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KMID : 0604520120380040297
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Journal of the Society of Cosmetic Scientists of Korea
2012 Volume.38 No. 4 p.297 ~ p.304
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Antioxidative Effect and Tyrosinase Inhibitory Activity of Lindera obtusiloba Blume Extracts
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Won Doo-Hyun
Han Seat-Byeol
Hwang Jun-Pil
Kim Su-Ji
Park Jin-Oh
Park Soo-Nam
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Abstract
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In this study, the antioxidative effects and inhibitory activities on tyrosinase of Lindera obtusiloba Blume (L. obtusiloba Blume) extracts were investigated. 50 % ethanol extract, ethyl acetate and aglycone fractions of L. obtusiloba Blume were used in experiments. The DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activities of ethyl acetate fraction of L. obtusiloba Blume was higher than (+)-α-tocopherol, known as a typical antioxidant. Reactive oxygen species (ROS) scavenging activities of extract and fractions of L. obtusiloba Blume on ROS generated in Fe3+-EDTA/H2O2 system were similar to L-ascorbic acid, well known as a strong antioxidant. The cellular protective effects of 50 % ethanol extract and ethyl acetate of L. obtusiloba Blume on the rose-bengal sensitized photohemolysis of human erythrocytes were increased in a concentration dependent manner (1 ~ 25 μg/mL). Ethyl acetate fraction in 10 μg/mL concentration showed the most protective effect among extracts (τ50 = 361.0 min). The inhibitory effects on tyrosinase of ethyl acetate and aglycone fractions were higher than arbutin, known as a whitening agent. These results indicate that L. obtusiloba Blume extracts can be used as antioxidant, and could be applicable to functional cosmetic ingredient.
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KEYWORD
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Lindera obtusiloba Blume, antioxidative activity, tyrosinase, photoaging
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